cd41 fitc cd42b pe antibodies (4A Biotech)
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cd41 fitc cd42b pe antibodies
Cd41 Fitc Cd42b Pe Antibodies, supplied by 4A Biotech, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/cd41/anti+cd41+conjugated+fitc/pm41936835-77-9-11
Average 86 stars, based on 1 article reviews
Cd41 Fitc Cd42b Pe Antibodies, supplied by 4A Biotech, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/cd41/anti+cd41+conjugated+fitc/pm41936835-77-9-11
Average 86 stars, based on 1 article reviews
cd41 fitc cd42b pe antibodies - by Bioz Stars,
2026-11
86/100 stars
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other:Article Title: Ferulic acid promotes thrombopoiesis via TLR4/JAK2/STAT3 signaling: A novel therapeutic strategy for thrombocytopenia. Article Snippet: Thrombocytopenia, a common hematological disorder, is associated with increased mortality in various diseases.. However, the existing clinical treatments are often accompanied by various adverse effects and may even disrupt platelet homeostasis, highlighting the urgent need to develop novel therapeutic agents.. Here, we developed a drug screening model based on virtual screening utilizing known monomeric components of Sanguisorba officinalis L. (SOL) and identified ferulic acid (FA) as a promising candidate for thrombocytopenia intervention. Article Title: Oxymatrine, a novel TLR2 agonist, promotes megakaryopoiesis and thrombopoiesis through the STING/NF-ĸB pathway Article Snippet: The cells 195 were then treated with 8 μM Article Title: Harmine promotes megakaryocyte differentiation and thrombopoiesis by activating the Rac1/Cdc42/JNK pathway through a potential target of 5-HTR2A. Article Snippet: School of Pharmacy, Southwest Medical University, Luzhou, China School of Basic Medical Sciences, Southwest Medical University, Luzhou, China Education Ministry Key Laboratory of Medical Electrophysiology, Sichuan Key Medical Laboratory of New Drug Discovery and Druggability Evaluation, Luzhou Key Laboratory of Activity Screening and Druggability Evaluation for Chinese Materia Medica, Southwest Medical University, Luzhou, China Article Title: Multimodal discovery of bavachinin A: A natural FLT3 agonist for treating thrombocytopenia. 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Article Title: Oxymatrine, a novel TLR2 agonist, promotes megakaryopoiesis and thrombopoiesis through the STING/NF-κB pathway Article Snippet: The cells were then treated with 8 μM Incubation:Article Title: Danthron as a novel IL-6R agonist promotes thrombopoiesis via the SRC/RAS/MAPK pathway Article Snippet: K562 and Meg-01 cells were cultured at the same density in cell culture plates and treated with danthron (2, 4, and 8 μM), PMA (1.25 nM) and SCH772984 (ERK inhibitor) (Topscience, Shanghai, China) or Tocilizumab (IL-6R inhibitor) (MedChemExpress, USA) for 5 days. .. Following the cleaning protocol outlined previously, the cells were incubated with Marker:Article Title: Epigallocatechin promotes megakaryocyte differentiation via ERα-dependent SRC/PI3K/AKT signaling for thrombocytopenia treatment. Article Snippet: Ethnopharmacological relevance: Sanguisorba officinalis L., a traditional Chinese hemostatic herb, is described in classical texts as having the dual function of “cooling and tonifying the blood.” Modern clinical studies have confirmed its significant efficacy against myelosuppression induced by cancer therapy, notably in elevating platelet counts in patients.. However, the specific active components responsible for this effect and their underlying mechanisms remain unelucidated.. Aim of the study: Building on the traditional hemostatic efficacy of Sanguisorba officinalis L., this study elucidates the effects and mechanisms of its active monomer, epigallocatechin (EGC), in promoting megakaryocyte differentiation and platelet production for the treatment of thrombocytopenia. Staining:Article Title: Epigallocatechin promotes megakaryocyte differentiation via ERα-dependent SRC/PI3K/AKT signaling for thrombocytopenia treatment. Article Snippet: Ethnopharmacological relevance: Sanguisorba officinalis L., a traditional Chinese hemostatic herb, is described in classical texts as having the dual function of “cooling and tonifying the blood.” Modern clinical studies have confirmed its significant efficacy against myelosuppression induced by cancer therapy, notably in elevating platelet counts in patients.. However, the specific active components responsible for this effect and their underlying mechanisms remain unelucidated.. Aim of the study: Building on the traditional hemostatic efficacy of Sanguisorba officinalis L., this study elucidates the effects and mechanisms of its active monomer, epigallocatechin (EGC), in promoting megakaryocyte differentiation and platelet production for the treatment of thrombocytopenia. Flow Cytometry:Article Title: Epigallocatechin promotes megakaryocyte differentiation via ERα-dependent SRC/PI3K/AKT signaling for thrombocytopenia treatment. Article Snippet: Ethnopharmacological relevance: Sanguisorba officinalis L., a traditional Chinese hemostatic herb, is described in classical texts as having the dual function of “cooling and tonifying the blood.” Modern clinical studies have confirmed its significant efficacy against myelosuppression induced by cancer therapy, notably in elevating platelet counts in patients.. However, the specific active components responsible for this effect and their underlying mechanisms remain unelucidated.. Aim of the study: Building on the traditional hemostatic efficacy of Sanguisorba officinalis L., this study elucidates the effects and mechanisms of its active monomer, epigallocatechin (EGC), in promoting megakaryocyte differentiation and platelet production for the treatment of thrombocytopenia. |
![18 Fr puncture of hemostasis in porcine aorta using VWP by validating the memory programming effect of each part. a, As a challenging model for application of large-diameter catheters, i) an 18 Fr (6 mm) puncture is created into the porcine thoracic aorta (diameter: 10 mm) so that the size-matched VWP is deployed, followed by measuring proximal and distal blood pressure. ii) The experimental groups are designed first to exam the memory programming effect of collaboration between Ring squeezing with Body expansion on self-locking (SL) to enable efficient hemostasis. Next, the effect of Wing shape recovery from curve to flat is examined on hemodynamic control (HC) in cooperation with the actions of Body and Ring to handle hemostasis. No recovery of Wing shape is expected to induce excessive thrombosis. iii) Four experimental groups are established using a total of 12 pigs (N = 12) with immediate sacrifice following deployment (N = 3 each). Group 1 [SL(−) HC(−)] represents no memory programming. Group 2 [SL(+) w/flat Wing] has the effects of Body and Ring actions except the hemostatic sealing by keeping the flat Wing. Group 3 [SL(+) HC(+)] possesses the complete memory effects of the three parts. Group 4 [SL(+) w/bump Wing] is expected to have excessive thrombosis because of no shape recovery from the curved Wing while maintaining the memory actions of Body and Wing. b, Each group is visually explained in the illustrations. c , In VWP actions, (left) the bleeding condition preserves the normal sinusoidal waveform of high proximal pressure (green) in contrast to the disturbed waveform of low distal pressure (red). (middle) Hemostatic closure results in similar high sinusoidal waveform at both pressure sites. (right) Excessive thrombosis does not disturb the waveform, but the distal pressure level becomes lower than the proximal one. d, When reperfusion starts by removing the clamp post-deployment (blue), only Group 3 [SL(+) HC(+)] reaches the hemostatic closure, as evidenced by flow stabilization (red) with a 5 s plateau at both pressure sites. Group 4 [SL(+) w/bump Wing] exhibits the pattern of over-thrombosis. e, H&E images show bleeding in Group 1 as an indication of incomplete closure in contrast to moderate, minimal, and dense thrombotic features observed in Group 2, 3, and 4 respectively as further supported by the signals of activated platelets (green, <t>CD41-positive)</t> and fibrinogen (red) [Scale bars = 0.5 mm (4 mm in box)]. f, Compared to Group 1 [SL(−) HC(−)] and 2 [SL(+) w/flat Wing], Group 3 [SL(+) HC(+)] shows the fastest i) hemostasis and ii) arterial pressure equilibration, indicating the most efficient hemostatic response. g, These outcomes in Group 3 include i) the smallest difference between the proximal and distal pressures with ii) the smallest thrombus area in contrast the largest area of Group 4 [SL(+) w/bump Wing] as an indication of excessive thrombosis. h , The marker gene expression of thrombotic feature (vWF, PF-4, and P-sel) significantly increases from Group 2 to Group 3 and further to Group 4 except the comparison of vWF expression between Group 2 and 3 (ns: no significance). Data are shown as mean ± SD, N = 3 biologically independent animals per group. Significance was determined using one-way ANOVA with Tukey's test between groups.](https://pub-med-central-images-cdn.bioz.com/pub_med_central_ids_ending_with_3994/pmc12803994/pmc12803994__gr4.jpg)